HOCl Publications

Hypochlorous Acid: An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency

The aim of this study was to investigate the effect of stabilized hypochlorous acid solution (HOCl) on killing rate, biofilm formation, antimicrobial activity within biofilm against frequently isol...

The National Necrotizing Fasciitis Foundation Says Current Standard of Care for Flesh-eating Bacteria is "Tragically Inadequate"

Neutralize toxins that eat away flesh by irrigating the wounds of necrotizing fasciitis patients with a substance called hypochlorous acid (HOCl), a natural chemical produced by white blood cells a...

Topical Hypochlorite Ameliorates NF-kB-Mediated Skin Diseases in Mice

Exposure of human keratinοcytes to 0.005% HOCl for 1 hour prior to TNF-α stimulation eliminated the induction of both genes.

Fibrin Clot Structure and Mechanics Associated with Specific Oxidation of Methionine Residues in Fibrinogen

Fibrinogen was oxidized by adding HOCl at physiologically relevant concentrations between 0–150 μmol HOCl/g fibrinogen (or ∼0–300 μM based on 2 mg/mL fibrinogen concentration) (22). Circular dichro...

Hypochlorous Acid as a Potential Wound Care Agent

HOCl is known to be the major strong oxidant produced by neutrophils, and is a potent microbicidal agent within these cells. Experimentally, it has been estimated that neutrophils stimulated in vit...

Stabilized Hypochlorous Acid: Its Role in Decreasing Tissue Bacterial Bioburden and Overcoming the Inhibition of Infection on Wound Healing

This stabilized form of hypochlorous acid (NVC-101) could have potential application as an antimicrobial wound irrigation and treatment solution if its effective pH range can be maintained in the c...

1915 Experimental Observations on the Antiseptic Action of Hypochlorous Acid and Its Application to Wound Treatment

In our observations on the hypochlorites we found that hypochlorous acid is a more potent germicide than its salts, and we have accordingly-devised a method in which the free acid is employed as th...