HOCl Publications

Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid

PLOS Pathogens: Here we show that hypochlorous acid, a disinfectant that is produced naturally by certain cells within the body, has strong anti-prion and anti-amyloid activity. We find that a non-...

Fibrin Clot Structure and Mechanics Associated with Specific Oxidation of Methionine Residues in Fibrinogen

Fibrinogen was oxidized by adding HOCl at physiologically relevant concentrations between 0–150 μmol HOCl/g fibrinogen (or ∼0–300 μM based on 2 mg/mL fibrinogen concentration) (22). Circular dichro...

Oxidative Modification of von Willebrand Factor by Neutrophil Oxidants Inhibits its Cleavage by ADAMTS13

We show in this study that neutrophil-derived oxidants are capable of readily oxidizing the methionine residue at the cleavage site for the VWF-processing enzyme ADAMTS13. 

Hypochlorous Acid as a Potential Wound Care Agent

HOCl is known to be the major strong oxidant produced by neutrophils, and is a potent microbicidal agent within these cells. Experimentally, it has been estimated that neutrophils stimulated in vit...

Efficacy of Electrolyzed Oxidizing Water for Inactivating Escherichia coli O157:H7, Salmonella enteritidis, and Listeria monocytogenes

American Society for MicrobiologySeptember, 1999AbstractThe efficacy of electrolyzed oxidizing water for inactivating Escherichia coli O157:H7, Salmonella enteritidis, and Listeria monocytogenes wa...

The Inhibition of Bacterial Growth by Hypochlorous Acid. Possible Role in the Bactericidal Activity of Phagocytes

These effects were apparent within 5 min of HOCl exposure, and were not reversed by extensive washings. DNA synthesis (incorporation of [3H]-thymidine) was significantly affected by even a 1 min ex...

1915 Experimental Observations on the Antiseptic Action of Hypochlorous Acid and Its Application to Wound Treatment

In our observations on the hypochlorites we found that hypochlorous acid is a more potent germicide than its salts, and we have accordingly-devised a method in which the free acid is employed as th...